Arkansas had lost to Alabama by a combined 33 points the past three seasons.
On Saturday, the No. 1 Crimson Tide handed the Razorbacks a 32-point loss, indicating Arkansas has taken another step back from the team that serves as the SEC's measuring stick.
Alabama dealt a mighty blow with Damien Harris' 75-yard touchdown on the game's first play from scrimmage, part of a big first quarter that ensured the game would never be close. The Crimson Tide also scored a field goal after Arkansas punter Blake Johnson dropped a snap and Harris scored a 4-yard touchdown to cap a 65-yard drive on Alabama's third possession.
The Crimson Tide (7-0, 4-0 SEC) led 17-0 less than eight minutes into the game.
Credit Arkansas for not completely rolling over like Vanderbilt and Ole Miss did against Alabama earlier this season. The Razorbacks' blitzing defense caused some problems for the Crimson Tide after the first few possessions and Arkansas trailed 24-0 at halftime.
It was an up-and-down first start for redshirt freshman quarterback Cole Kelley, who got the nod when Austin Allen was unable to play because of a shoulder injury suffered last week. Kelley completed 23 of 42 passes for 200 yards, 1 touchdown and 1 interception.
Kelley was without the benefit of a run game. The Razorbacks rushed for just 27 yards on 29 attempts and Kelley had the team's longest run - a 13-yard scramble on a third down to set-up Arkansas' first score in the third quarter.
Some poor technique led to Kelley missing some throws. Most notably he threw off his back foot on multiple occasions, including on his interception in the fourth quarter.
Like Allen the five games before, Kelley spent much of the game dodging defenders. Even with Kelley in the Shotgun most of the game, Alabama had five sacks and hurried him 11 times.
Kelley played behind an offensive line that was unlike any the Razorbacks had fielded through the first five games. Zach Rogers (center) and Brian Wallace (right tackle) made their first starts of the season, while Frank Ragnow (right guard) and Johnny Gibson (left tackle) made their first starts at a new position.
Only left guard Hjalte Froholdt was in the same position as last week, and he was knocked back multiple times during the second half.
Alabama dominated in nearly every facet, but especially at the line of scrimmage. The Crimson Tide out-gained Arkansas 308-27 on the ground - the Hogs' worst discrepancy since Auburn out-gained the team by more than 500 yards in a blowout win last season.
The Razorbacks have been out-gained 851-52 in rushing yards in their past two trips to the Yellowhammer State.
Arkansas' defense did not contain the Crimson Tide's cutback lanes well. Harris' opening score was benefitted by a cutback, as were at least five lengthy Alabama runs.
On the positive side, the Razorbacks were able to force two turnovers. Alabama had committed only one in its previous 638 plays entering the game.
Arkansas fell to 0-11 against Alabama during the Nick Saban era and lost to a Saban-coached team for the 13th consecutive time. The average margin of defeat in those games has been 24.8 points.
The Razorbacks were a 35-point underdog, according to the oddsmakers, but the margin of loss isn't likely to sit well with many fans who hoped the team would show better than last week's 26-point blowout at South Carolina.
Arkansas (2-4, 0-3 SEC) now has lost six straight games to Power 5 opponents, including three this year by 21 points or more. That isn't likely to help the dissatisfaction with Coach Bret Bielema, who fell to 10-25 in SEC games and to three games below .500 overall in his fifth season.
If the Razorbacks are to avoid a seventh straight Power 5 loss, they will have to do it as an underdog against Auburn at home next Saturday night. The Tigers (5-2, 3-1 SEC) were one of three top 10 teams to lose this weekend, blowing a 20-point lead in a 27-23 loss at LSU.